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From I-70:

Take the Highway 19 South exit (#175). Go south 15 miles and cross the Missouri River bridge into Hermann. Continue south on 19 (Market Street). Hermann Motel will be on your left, just up the hill from the Frene Creek Bridge. Turn left on 10th Street into the parking lot.

From I-44 traveling west from St. Louis:

Take Highway 100 West exit (#251). Continue west on 100 through Washington and New Haven. In Hermann, turn left on Highway 19 (Market Street). Hermann Motel will be on your left, just up the hill from the Frene Creek Bridge. Turn left on 10th Street into the parking lot.

From I-44 traveling east from Springfield:

Take the Highway 19 North exit (#208). Go north 50 miles to Hermann. Continue north on 19 (Market Street). Hermann Motel will be on your right. Turn right on 10th Street into the parking lot.